BillionToOne to present a novel method to quantify the abundance of nucleic acid species at 20th AGBT Conference

<p class="news__date"><img decoding="async" class="size-full wp-image-148 aligncenter" src="/billiontoone-to-present-a-novel-method-to-quantify-the-abundance-of-nucleic-acid-species-at-20th-agbt-conference/content_1755694810_20thAnniversary_final.png" alt="" width="274" /></p><p>BillionToOne, a venture-backed precision diagnostics company, is presenting a poster at <a title="" href="https://www.agbt.org/the-general-meeting/">20th Advances in Genome Biology and Technology Conference</a> about a novel method to quantify the abundance of nucleic acid that spans over several orders of magnitude while significantly reducing the number of required sequencing reads.</p><p><strong>Dilution Tagging: A novel method to quantify the abundance of nucleic acid species with high dynamic range. </strong></p><p>Nucleic acid (DNA and RNA) abundances in a single sample can span many orders of magnitude. In applications like characterization of T cell receptor population and RNA transcriptome measurements, quantifying molecules across many orders of magnitude, i.e., high dynamic range, is critical to understanding important developmental or disease states.</p><p>Current methods to quantify either DNA or RNA with high dynamic range, quantitative real-time PCR (qPCR) and unique molecular identifiers (UMIs), have limitations. BillionToOne developed a patent-pending, novel assay called dilution tagging that allows nucleic acid quantification over several orders of magnitude while significantly reducing the number of required sequencing reads.</p><p>In the poster presentation, we show that dilution tagging highly correlates with UMI based counting and is up to 62x more efficient than UMI-based counting.</p><p>For any inquiries, please email <a href="mailto:support@billiontoone.com">support@billiontoone.com</a></p>